Evaluation of main functional dyspepsia symptoms after probiotic administration in patients receiving conventional pharmacological therapies

Objective Postprandial distress syndrome (PDS) and epigastric pain (EPS) are the two main forms of functional dyspepsia (FD). Probiotics a promising therapy for FD, but current data remains heterogeneous. This work aims to evaluate probiotic combination Lacticaseibacillus rhamnosus LR04 (DSM 16605), Lactiplantibacillus pentosus LPS01 21980), plantarum LP01 (LMG P-21021), Lactobacillus delbrueckii subsp. delbruekii LDD01 (DMS 22106), alone or together with other pharmacological therapies, clinical improvement symptoms associated FD. Methods Patients FD were enrolled divided into groups: PDS EPS. Probiotic combined prokinetics, antacids, proton-pump-inhibitors administered 30 days. A progressive-score scale was used in all patients at beginning trial 15 days after end treatment. Results cohort 2676 (1 357 PDS; 1 319 EPS). All showed significant improvements dyspeptic following In PDS, resulted lowest prevalence treatment, while EPS no clear between-treatment differences. Conclusions Dyspeptic reduced treatment patients.